11 September
17:30 – 19:30 Core group meeting
19:30 welcome dinner
12 September, Wednesday
Location: Hotel Grand Spa Lietuva, Nemunas Hall
Welcome address - Vytautas Smirnovas & Silvio Tosatto 8:50 - 9:00
Session 1, chair: Vytautas Smirnovas
Invited talk - Ronald Melki - Prion-like propagation of alpha-synuclein protein assemblies in Parkinson’s disease and related synucleinopathies 9:00 - 9:30
Ludmilla Morozova-Roche - Linking amyloid and neuroinflammatory cascades in neurodegenerative diseases – role of pro-inflammatory S100A9 protein 9:30 - 9:50
Salvador Ventura - A novel small molecule inhibits α-synuclein aggregation, disrupts amyloid fibrils and prevents degeneration of dopaminergic neurons 9:50 - 10:10
Georgios Skretas - Engineering bugs for the discovery of new drugs against diseases caused by protein misfolding and aggregation 10:10 - 10:30
Coffee Break 10:30 - 11:00
WG meetings - WG4 and WG2 11:00 - 12:30
Lunch, Hotel restaurant 12:30 - 14:00
Session 2, chair: Salvador Ventura
Invited talk - Witold K. Surewicz – Amyloid fibrils from the N-terminal prion protein fragment as a model for studying the mechanism of prion propagation and transmissibility barriers 14:00 - 14:30
Andrei Kajava - Structural aspects of naturally-occurring amyloids 14:30 - 14:50
Kristaps Jaudzems - Biomimicry of Artificial Spider Silk Spinning Assessed by NMR Spectroscopy 14:50 - 15:10
Flash poster presentations, I session 15:10 - 15:35
Poster Session and Coffee Break 15:35 - 17:00
Session 3, chair: Sandra Macedo-Ribeiro
Invited talk – Meytal Landau – Extreme Polymorphism in Amyloids from Pathogenic Microbes 17:00 - 17:30
Gunilla Westermark - Cross-seeding of amyloid as a link between diabetes and Alzheimer’s disease 17:30 - 17:50
Gil Rosenman - Nanophotonics of Amyloid Peptide Nanostructures 17:50 - 18:10
Edoardo Salladini - Liquid-liquid phase separation by a viral protein as an additional molecular mechanism of virus-induced cell toxicity 18:10 - 18:30
Dinner, Rooftop Hotel restaurant 19:30 -
13 September, Thursday
Location: Hotel Grand Spa Lietuva, Nemunas Hall
Session 1, chair: Andrei Lupas
Invited talk - Kjetill Sigurd Jakobsen - Hypervariable coding short tandem repeats as modulators of protein function 9:00 - 9:30
Fabio Parmeggiani - Custom Protein Design from Modular Building Blocks 9:30 - 9:50
Flash poster presentations, II session 9:50 - 10:30
Coffee Break 10:30 - 11:00
WG meetings - WG1 and WG3 11:00 - 12:30
Lunch, Hotel restaurant 12:30 - 14:00
Session 2, chair: Andrey Kajava
Invited talk - Drew Thomson - Computational Design of Alpha-Helical Barrels 14:00 - 14:30
Invited talk - Maria Anisimova - A census of protein tandem repeats and their relationship with intrinsic disorder 14:30 - 15:00
Andrei Lupas - Hexads and nonads specify a new type of coiled-coil fiber 15:00 - 15:20
Aitziber L. Cortajarena - Design of artificial antennas and electron transfer chains on repeated scaffolds 15:20 - 15:40
Coffee Break 15:40 - 16:10
MC meeting and student event (parallel sessions) 16:10 - 18:30
Dinner, Hotel restaurant 19:30 -
14 September, Friday
Location: Hotel Grand Spa Lietuva, Nemunas Hall
Session 1, chair: Jurij Lah
Invited talk - Motonori Ota - Property of intrinsically disordered "hub" proteins 9:00 - 9:30
Petri Kursula - Intrinsic Disorder and Myelin Protein Complexes 9:30 - 9:50
Julia Marchetti - Towards biologically meaningful ensembles in disordered proteins 9:50 - 10:10
Pedro Pereira - Specific modulation of the anticoagulant activity of madanin-1 by tyrosine sulfation 10:10 - 10:30
Coffee Break 10:30 - 11:00
Session 2, chair: Kristina Djinovic-Carugo
Invited talk - Attila Remenyi - Tales of tails: the role of disordered protein kinase regions in the regulation and assembly of kinase domain cores 11:00 - 11:30
Laura Weidmann - The Power of Reuse in the Evolution of natural Proteins 11:30 - 11:50
Pietro Sormanni - Rational design of antibodies targeting specific epitopes within disordered proteins: applications in the study of neurodegeneration 11:50 - 12:10
Flash poster presentations, III session 12:10 - 12:30
Lunch, Hotel restaurant 12:30 - 14:00
Session 3, chair: Oxana Galzitskaya
Invited talk - Isabelle Callebaut - Looking at disorder and disorder-to-order transitions using Hydrophobic Cluster Analysis 14:00 - 14:30
Wim Vranken - Exploring the Sequence-based Prediction of Folding Initiation Sites in Proteins 14:30 - 14:50
Marcin Grynberg - ClusterLCR: a new tool to compare low complexity regions in unlike proteins 14:50 - 15:10
Flash poster presentations, IV session 15:10 - 15:30
Poster Session and Coffee Break 15:30 - 17:00
Session 4, chair: Sonia Longhi
Invited talk - Richard W. Kriwacki - Phase Separation in Biology and Disease 17:00 - 17:30
Jordan Chill - Mechanistic Aspects of IDP Binding and Signaling Studied by NMR 17:30 - 17:50
Lukáš Žídek - Structure-function relationship in disordered proteins: knowledge acquired by NMR studies of microtubule associated proteins 17:50 - 18:10
San Hadži - Promiscuous intrinsically disordered tail from bacterial repressor mediates binding to the operator 18:10 - 18:30
Closing address 18:30 - 18:40
Dinner, Hotel restaurant 19:30 -